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| IJMEG Copyright © 2010-present. All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711 |
Int J Mol Epidemiol Genet 2010;1(1):31-34.
Commentary
Credible genetic associations?
Marcus R. Munafò
Department of Experimental Psychology, University of Bristol, United Kingdom
Received August 12, 2009; accepted September 26, 2009; available online October 5, 2009
Abstract: The proliferation in genetic association studies, and the recurring failure of initially promising findings to robustly
replicate, demonstrates the need for stringent standards to ensure the identification of credible associations. The Human
Genome Epidemiology Network has recently published intermin guideliness on evidential criteria for genetic association
studies. These are reviewed, and their value and importance discussed, as well as the impact these guidelines will have on
the conduct of genetic association studies. (IJMEG908001).
Key words: Genetic association; replication; HuGENet; Meta-Analysis
Full Text PDF
Address all correspondence to:
Marcus R. Munafò, PhD
Department of Experimental Psychology
University of Bristol
12a Priory Road, Bristol BS8 1TU
United Kingdom.
Tel: +44.117.9546841; Fax: +44.117.9288588
E-mail: marcus.munafo@bristol.ac.uk
Commentary
Credible genetic associations?
Marcus R. Munafò
Department of Experimental Psychology, University of Bristol, United Kingdom
Received August 12, 2009; accepted September 26, 2009; available online October 5, 2009
Abstract: The proliferation in genetic association studies, and the recurring failure of initially promising findings to robustly
replicate, demonstrates the need for stringent standards to ensure the identification of credible associations. The Human
Genome Epidemiology Network has recently published intermin guideliness on evidential criteria for genetic association
studies. These are reviewed, and their value and importance discussed, as well as the impact these guidelines will have on
the conduct of genetic association studies. (IJMEG908001).
Key words: Genetic association; replication; HuGENet; Meta-Analysis
Full Text PDF
Address all correspondence to:
Marcus R. Munafò, PhD
Department of Experimental Psychology
University of Bristol
12a Priory Road, Bristol BS8 1TU
United Kingdom.
Tel: +44.117.9546841; Fax: +44.117.9288588
E-mail: marcus.munafo@bristol.ac.uk
