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Int J Mol Epidemiol Genet 2010;1(4):367-376.
Original Article
Adducin 1 (alpha) Gly460Trp variant is associated with left ventricular
geometry in Caucasians and African Americans: The HyperGEN Study
Krati Chauhan, Richard B. Devereux, D.C. Rao, Ulrich Broeckel, Charles C. Gu, Paul Hopkins, Donna K. Arnett
Department of Epidemiology, University of Alabama at Birmingham, AL, USA; Division of Cardiology, Weill Cornell Medical
College, New York, NY, USA; Division of Biostatistics, Washington University in St. Louis, MO, USA; Department of Medicine,
Medical College of Wisconsin, Milwaukee, WI, USA; Cardiovascular Genetics, University of Utah, Salt Lake City, UT, USA.
Received December 31, 2009, accepted February 21, 2010, available online February 26, 2010
Abstract: Normal left ventricular (LV) mass and geometry is required for optimal LV functioning. Abnormalities in either
result in increased morbidity and mortality. The adducing 1 (alpha) gene (ADD1) Gly460Trp polymorphism has been
associated with high blood pressure and increased plasma volume, both predictors of LV mass and function. In
this cross-sectional study, we evaluate the association between this polymorphism and LV mass and geometry. LV mass,
relative wall thickness (RWT), and systolic and diastolic parameters were measured using echocardiography in 3483 African
American and Caucasian subjects from the Hypertension Genetic Epidemiology Network (HyperGEN). Analysis of covariance
was used to estimate the polymorphism’s association with echocardiograph parameters, stratified by race. The model was
adjusted for age, diastolic and systolic blood pressure, glomerular filtration rate, smoking, low and high density lipoprotein
cholesterol, urinary sodium, and body mass index. In Caucasians, the Trp allele was associated with higher ejection fraction
(EF) (P = .02), fractional shortening (FS) (P = .02), and RWT (P = .03). In African Americans, the Trp allele was negatively
associated with RWT (P = .02), but no association was found with EF (P = .08) or FS (P = .09). The polymorphism was not
associated with diastolic function parameters in either racial group. We found no association of ADD1 Gly460Trp with LV mass
in Caucasians or African Americans; however, it was associated with unfavorable LV geometry (higher RWT) in Caucasians
and favorable LV geometry (lower RWT) in African Americans after controlling for factors that would affect plasma volume.
(IJMEG912005).
Key words: Adducin, genetic polymorphism, left ventricular mass, left ventricular geometry, hypertrophy
Full Text PDF
Address all correspondence to:
Donna K. Arnett, PhD
UAB RPHB 220E 1530 3rd Avenue South
Birmingham AL 35294-0022, USA.
Tel: 205-934-7066, Fax: 205-934-8665
E-mail: arnett@uab.edu
Original Article
Adducin 1 (alpha) Gly460Trp variant is associated with left ventricular
geometry in Caucasians and African Americans: The HyperGEN Study
Krati Chauhan, Richard B. Devereux, D.C. Rao, Ulrich Broeckel, Charles C. Gu, Paul Hopkins, Donna K. Arnett
Department of Epidemiology, University of Alabama at Birmingham, AL, USA; Division of Cardiology, Weill Cornell Medical
College, New York, NY, USA; Division of Biostatistics, Washington University in St. Louis, MO, USA; Department of Medicine,
Medical College of Wisconsin, Milwaukee, WI, USA; Cardiovascular Genetics, University of Utah, Salt Lake City, UT, USA.
Received December 31, 2009, accepted February 21, 2010, available online February 26, 2010
Abstract: Normal left ventricular (LV) mass and geometry is required for optimal LV functioning. Abnormalities in either
result in increased morbidity and mortality. The adducing 1 (alpha) gene (ADD1) Gly460Trp polymorphism has been
associated with high blood pressure and increased plasma volume, both predictors of LV mass and function. In
this cross-sectional study, we evaluate the association between this polymorphism and LV mass and geometry. LV mass,
relative wall thickness (RWT), and systolic and diastolic parameters were measured using echocardiography in 3483 African
American and Caucasian subjects from the Hypertension Genetic Epidemiology Network (HyperGEN). Analysis of covariance
was used to estimate the polymorphism’s association with echocardiograph parameters, stratified by race. The model was
adjusted for age, diastolic and systolic blood pressure, glomerular filtration rate, smoking, low and high density lipoprotein
cholesterol, urinary sodium, and body mass index. In Caucasians, the Trp allele was associated with higher ejection fraction
(EF) (P = .02), fractional shortening (FS) (P = .02), and RWT (P = .03). In African Americans, the Trp allele was negatively
associated with RWT (P = .02), but no association was found with EF (P = .08) or FS (P = .09). The polymorphism was not
associated with diastolic function parameters in either racial group. We found no association of ADD1 Gly460Trp with LV mass
in Caucasians or African Americans; however, it was associated with unfavorable LV geometry (higher RWT) in Caucasians
and favorable LV geometry (lower RWT) in African Americans after controlling for factors that would affect plasma volume.
(IJMEG912005).
Key words: Adducin, genetic polymorphism, left ventricular mass, left ventricular geometry, hypertrophy
Full Text PDF
Address all correspondence to:
Donna K. Arnett, PhD
UAB RPHB 220E 1530 3rd Avenue South
Birmingham AL 35294-0022, USA.
Tel: 205-934-7066, Fax: 205-934-8665
E-mail: arnett@uab.edu
